Return to Epler.com Tables Bronchiolar Airway Disorders and Bronchiolitis Obliterans Gary R. Epler, M.D. Return to article pg. 1 TABLE 1. Historic Perspective of Bronchiolar Disorders 1901   Bronchiolitis obliterans 1902   Fume related bronchiolitis obliterans 1904   Post infection bronchiolitis obliterans 1977   Connective tissue disease-related bronchiolitis obliterans 1977   Drug-related bronchiolitis obliterans 1982   Bone marrow transplantation bronchiolitis obliterans 1983   Diffuse panbronchiolitis 1984   Heart-lung transplantation obliterative bronchiolitis 1985   Idiopathic BOOP 1987   Respiratory bronchiolitis-interstitial lung disease 1989   Lung transplantation obliterative bronchiolitis 1992   Neuroendocrine cell hyperplasia with airflow obstruction Return to article pg. 1 TABLE 2. Airway Anatomy   Structure Feature   Bronchus Cartilage, mucous glands, ciliated epithelium, smooth muscle   Bronchioles Ciliated epithelium, smooth muscle   Terminal bronchioles Ciliated and non-ciliated epithelium, few basal cells, smooth muscle   Respiratory bronchioles Non ciliated columnar, ciliated columnar and basal cells Non ciliated cuboidal cells Nonciliated cuboidal type II cells and squamous type I cells Alveoli in walls Return to article pg. 1 TABLE 3. Pathological Features of Constrictive Bronchiolitis Irreversible scarring and alteration of bronchioles that may include:   Complete fibrous obliteration of bronchioles Dilatation of airways with mucus stasis Acute or chronic inflammation in the wall Acute lumenal inflammation Distal airspaces may show effects of obstruction Stenosis from concentric or eccentric mural fibrosis or submucosal granulation tissue formation Return to article pg. 2 Table 4. Clinical Classification of the Diseases of the Bronchioles Bronchiolar disorders of the airways Acute or chronic cellular bronchiolitis Follicular bronchiolitis Mineral dust bronchiolitis Cigarette smoke respiratory bronchiolitis Diffuse panbronchiolitis Constrictive bronchiolitis Idiopathic Post fume exposure Postinfection Rheumatologic or connective-tissue disorders Drug reaction Post bone marrow transplantation Post lung transplantation Miscellaneous Aspiration Stevens-Johnson syndrome Carcinoid Primary biliary cirrhosis Sauropus androgynus Interstitial lung disease with bronchiolar involvement Respiratory bronchiolitis-interstitial lung disease Bronchiolitis obliterans organizing pneumonia (BOOP) Return to article pg. 3 TABLE 5.Bronchiolitis Obliterans (Constrictive Bronchiolitis Pattern) Compared to Bronchiolitis Obliterans Organizing Pneumonia (BOOP) Description Bronchiolitis Obliterans BOOP* General Airflow disorder Interstitial disorder Pathological findings Constrictive bronchiolitis Proliferative bronchiolitis obliterans, org. pneumonia Chest examination Early crackles Late crackles Chest radiograph Normal Patchy infiltrates Pulmonary function Abnormal FEV, and FEV,/FVC percentage Abnormal vital capacity and Dsb Therapy response Poor Good Prognosis Poor Good   Return to Epler.com